3 days ago

Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 7 hours agoStatus: Live

Job Summary

Drive in vitro and cellular pharmacology work within Translational Sciences, designing biological screening cascades and optimizing biophysical/biochemical assays (e.g., SPR, ITC) and functional/phenotypic cellular assays. Oversee CRO experiments, translate computational predictions into testable hypotheses, and synthesize binding/kinetic/dose-response data to support IND-enabling packages. Collaborate closely with ML/data science, medicinal chemistry, structural biology, and in vivo/translational teams across oncology, immunology, and partnership programs.

Location: Cambridge

Workplace: Hybrid

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Mid level

Key Responsibilities

•Design efficient biological screening cascades for internal and partnered drug design programs.
•Optimize and implement biophysical and biochemical assays (including SPR, ITC, and enzymatic methods) to evaluate target interaction, potency, and specificity.
•Develop and refine functional and phenotypic cellular assays to advance target validation and mechanistic understanding.
•Partner with CROs to design decision-making experiments and deliver high-quality biological data to guide clinical paths.
•Evaluate and synthesize binding, kinetic, and dose-response information, and produce technical documentation to support IND-enabling data packages.

Key Requirements

•Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or a related scientific discipline.
•Extensive experience designing and implementing biological screening cascades across drug design projects from hit identification to candidate selection.
•Deep knowledge of experimental in vitro pharmacology techniques, including biophysical, biochemical, and/or cellular assays.
•Ability to provide technical guidance in matrixed organizations and steer cross-functional programs through collaboration.
•Experience working with CROs to acquire and interpret high-quality biological data in a timely manner.

Education:PhD / Doctorate

Skills:CommunicationCollaborationCritical thinkingTechnical guidanceAgility

Languages:English

Tech Stack:Machine learningAI/MLAlphaFoldIn silicoDrug discoveryScreening cascadesBiophysical assaysBiochemical assaysCellular assaysSPRITCEnzymatic methodologiesSARCROBinding dataKinetic dataDose-response dataIND-enabling data packagesData ingestionMolecular glue

Company Brief

Isomorphic Labs

Uses machine learning and computational biology to accelerate drug discovery and design novel therapeutics by modeling protein structures, mechanisms, and interactions to identify promising targets and candidates.

Industry: Biotech

Company Size: Medium (51 to 250 employees)

Growth: Growth Stage Startup

Headquarters: London, United Kingdom

Founded: 2021

Website LinkedIn

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Isomorphic Labs

3 days ago

Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 7 hours agoStatus: Live

Job Summary

Location: Cambridge

Workplace: Hybrid

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Mid level

Key Responsibilities

•Design efficient biological screening cascades for internal and partnered drug design programs.
•Optimize and implement biophysical and biochemical assays (including SPR, ITC, and enzymatic methods) to evaluate target interaction, potency, and specificity.
•Develop and refine functional and phenotypic cellular assays to advance target validation and mechanistic understanding.
•Partner with CROs to design decision-making experiments and deliver high-quality biological data to guide clinical paths.
•Evaluate and synthesize binding, kinetic, and dose-response information, and produce technical documentation to support IND-enabling data packages.

Key Requirements

•Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or a related scientific discipline.
•Extensive experience designing and implementing biological screening cascades across drug design projects from hit identification to candidate selection.
•Deep knowledge of experimental in vitro pharmacology techniques, including biophysical, biochemical, and/or cellular assays.
•Ability to provide technical guidance in matrixed organizations and steer cross-functional programs through collaboration.
•Experience working with CROs to acquire and interpret high-quality biological data in a timely manner.

Education:PhD / Doctorate

Skills:CommunicationCollaborationCritical thinkingTechnical guidanceAgility

Languages:English

Company Brief

Isomorphic Labs

Industry: Biotech

Company Size: Medium (51 to 250 employees)

Growth: Growth Stage Startup

Headquarters: London, United Kingdom

Founded: 2021

Website LinkedIn