Scientist II, Genomic Core

Xaira Therapeutics
United States
Workplace: OnsiteFull timeUSD 124,000 - 155,000 annuallyFunction: Research & Scientific (R&D)Skills: ["Independent scientific thinking","Technical leadership","Troubleshooting","Problem-solving","Cross-functional communication"]

Serve as a hands-on technical leader on the Genomics Core team, generating high-quality sequencing data that powers an AI-driven discovery platform. Design, develop, optimize, validate, and execute Illumina NGS workflows (MiSeq, NextSeq, NovaSeq) and 10x Genomics assays. Support CRISPR-based perturbation studies, single-cell genomics, and targeted sequencing by collaborating with Functional Genomics, Automation, and Computational Biology teams, while maintaining QC and lab documentation systems.

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FursaFursa
Xaira Therapeutics
Xaira Therapeutics
1 month ago

Scientist II, Genomic Core

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Source: Company careers pageValidated by: Fursa AI
Last checked: 5 hours agoStatus: Live

Job Summary

Serve as a hands-on technical leader on the Genomics Core team, generating high-quality sequencing data that powers an AI-driven discovery platform. Design, develop, optimize, validate, and execute Illumina NGS workflows (MiSeq, NextSeq, NovaSeq) and 10x Genomics assays. Support CRISPR-based perturbation studies, single-cell genomics, and targeted sequencing by collaborating with Functional Genomics, Automation, and Computational Biology teams, while maintaining QC and lab documentation systems.
Location: United States
Workplace: Onsite
Employment Type: Full time
Job Function: Research & Scientific (R&D)
Seniority: Mid level

Key Responsibilities

  • •Perform high-quality NGS operations across Illumina platforms (MiSeq, NextSeq, NovaSeq).
  • •Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.
  • •Prepare and QC sequencing libraries for applications including 10x Genomics single-cell RNA-seq, bulk RNA-seq, CRISPR-based assays, and targeted sequencing workflows.
  • •Collaborate with Functional Genomics, Automation, and Computational Biology teams to support Perturb-seq, pooled CRISPR screening, and downstream AI/ML-ready analysis-quality data.
  • •Maintain sequencing sample intake, experimental tracking, reagent inventory, and documentation using ELN and LIMS while calibrating and troubleshooting instrumentation.

Pay and Benefits

Salary: USD 124,000 - 155,000 annually
Equity and Bonus:Equity

Key Requirements

  • •Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
  • •Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
  • •Extensive hands-on experience with 10x Genomics workflows (e.g., 3’, 5’, ATAC, Multiome, Flex).
  • •Strong expertise in NGS library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
  • •Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.
Skills:Independent scientific thinkingTechnical leadershipTroubleshootingProblem-solvingCross-functional communication
Languages:English
Tech Stack:IlluminaMiSeqNextSeqNovaSeq10x Genomics3’5’ATACMultiomeFlexCRISPRPerturb-seqPooled CRISPR screensGuide sequencingSingle-cell RNA-seqBulk RNA-seqTargeted sequencingELNLIMSBioinformatics

Company Brief

Xaira Therapeutics
Xaira Therapeutics is a biotechnology company developing novel targeted therapeutics using proprietary discovery platforms to address serious unmet medical needs. The company focuses on advancing preclinical and clinical-stage programs toward regulatory approval and commercialization.
Industry: Biotech
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