Xaira Therapeutics

1 day ago

Scientist II, Genomic Core

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 17 hours agoStatus: Live

Job Summary

Serve as a hands-on technical leader on the Genomics Core team, generating high-quality sequencing data that powers an AI-driven discovery platform. Design, develop, optimize, validate, and execute Illumina NGS workflows (MiSeq, NextSeq, NovaSeq) and 10x Genomics assays. Support CRISPR-based perturbation studies, single-cell genomics, and targeted sequencing by collaborating with Functional Genomics, Automation, and Computational Biology teams, while maintaining QC and lab documentation systems.

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Mid level

Key Responsibilities

•Perform high-quality NGS operations across Illumina platforms (MiSeq, NextSeq, NovaSeq).
•Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.
•Prepare and QC sequencing libraries for applications including 10x Genomics single-cell RNA-seq, bulk RNA-seq, CRISPR-based assays, and targeted sequencing workflows.
•Collaborate with Functional Genomics, Automation, and Computational Biology teams to support Perturb-seq, pooled CRISPR screening, and downstream AI/ML-ready analysis-quality data.
•Maintain sequencing sample intake, experimental tracking, reagent inventory, and documentation using ELN and LIMS while calibrating and troubleshooting instrumentation.

Pay and Benefits

Salary: USD 124,000 - 155,000 annually

Equity and Bonus:Equity

Key Requirements

•Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
•Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
•Extensive hands-on experience with 10x Genomics workflows (e.g., 3’, 5’, ATAC, Multiome, Flex).
•Strong expertise in NGS library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
•Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.

Skills:Independent scientific thinkingTechnical leadershipTroubleshootingProblem-solvingCross-functional communication

Languages:English

Tech Stack:IlluminaMiSeqNextSeqNovaSeq10x Genomics3’5’ATACMultiomeFlexCRISPRPerturb-seqPooled CRISPR screensGuide sequencingSingle-cell RNA-seqBulk RNA-seqTargeted sequencingELNLIMSBioinformatics

Company Brief

Xaira Therapeutics

Xaira Therapeutics is a biotechnology company developing novel targeted therapeutics using proprietary discovery platforms to address serious unmet medical needs. The company focuses on advancing preclinical and clinical-stage programs toward regulatory approval and commercialization.

Industry: Biotech

Website

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Xaira Therapeutics

1 day ago

Scientist II, Genomic Core

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 17 hours agoStatus: Live

Job Summary

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Mid level

Key Responsibilities

•Perform high-quality NGS operations across Illumina platforms (MiSeq, NextSeq, NovaSeq).
•Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.
•Prepare and QC sequencing libraries for applications including 10x Genomics single-cell RNA-seq, bulk RNA-seq, CRISPR-based assays, and targeted sequencing workflows.
•Collaborate with Functional Genomics, Automation, and Computational Biology teams to support Perturb-seq, pooled CRISPR screening, and downstream AI/ML-ready analysis-quality data.
•Maintain sequencing sample intake, experimental tracking, reagent inventory, and documentation using ELN and LIMS while calibrating and troubleshooting instrumentation.

Pay and Benefits

Salary: USD 124,000 - 155,000 annually

Equity and Bonus:Equity

Key Requirements

•Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
•Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
•Extensive hands-on experience with 10x Genomics workflows (e.g., 3’, 5’, ATAC, Multiome, Flex).
•Strong expertise in NGS library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
•Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.

Skills:Independent scientific thinkingTechnical leadershipTroubleshootingProblem-solvingCross-functional communication

Languages:English

Tech Stack:IlluminaMiSeqNextSeqNovaSeq10x Genomics3’5’ATACMultiomeFlexCRISPRPerturb-seqPooled CRISPR screensGuide sequencingSingle-cell RNA-seqBulk RNA-seqTargeted sequencingELNLIMSBioinformatics

Company Brief

Xaira Therapeutics

Industry: Biotech

Website