(Senior) Director, Translational Medicine and Diagnostics

Insitro
United States
Workplace: HybridFull timeUSD 224,000 - 299,000 annuallyFunction: Executive & General ManagementExperience: 10+ yearsSkills: ["Cross-functional collaboration","Leadership","Communication","Interpersonal skills","Patient-driven mindset"]

Lead the translational medicine function, driving strategy from IND/CTA through clinical proof-of-concept across biologics, oligonucleotides, and small molecules. Own end-to-end translational planning, GCP adherence, and regulatory-authority interactions, including biospecimen CRO oversight. Build biomarker and patient stratification approaches using laboratory and digital biomarkers to generate proof-of-mechanism evidence and enable timely go/no-go decisions. Collaborate across clinical, preclinical, regulatory, and computational teams and help shape AI/ML translational science.

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FursaFursa
Insitro
Insitro
1 month ago

(Senior) Director, Translational Medicine and Diagnostics

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Last checked: 6 hours agoStatus: Live

Job Summary

Lead the translational medicine function, driving strategy from IND/CTA through clinical proof-of-concept across biologics, oligonucleotides, and small molecules. Own end-to-end translational planning, GCP adherence, and regulatory-authority interactions, including biospecimen CRO oversight. Build biomarker and patient stratification approaches using laboratory and digital biomarkers to generate proof-of-mechanism evidence and enable timely go/no-go decisions. Collaborate across clinical, preclinical, regulatory, and computational teams and help shape AI/ML translational science.
Location: United States
Workplace: Hybrid
Employment Type: Full time
Job Function: Executive & General Management
Seniority: Director level

Key Responsibilities

  • •Build and lead the translational medicine function from IND/CTA through clinical proof-of-concept across biologics, oligonucleotides, and small molecules.
  • •Serve as translational lead for advanced pre-clinical and initial clinical-stage assets.
  • •Own end-to-end translational strategy, including GCP adherence and regulatory-authority interactions plus biospecimen CRO selection and oversight.
  • •Design biomarker-driven patient stratification strategies and generate proof-of-mechanism evidence to support go/no-go decisions.
  • •Interpret regulatory translational medicine requirements, partner with preclinical/clinical/regulatory/computational teams, and influence AI/ML policy through publications and stakeholder engagement.

Pay and Benefits

Salary: USD 224,000 - 299,000 annually
Perks:401kHealth InsuranceDentalVisionAnnual BonusEquityParental LeaveLearning BudgetHome OfficeCell PhoneCommuter Benefits

Key Requirements

  • •Advanced degree in life sciences, technology, chemistry, or related field (or equivalent practical experience).
  • •10+ years of translational science experience in biotech and/or pharma, including serving as translational lead from FIH through proof-of-concept to NDA/BLA submission.
  • •Experience applying AI/ML approaches to drug discovery and development.
  • •Deep understanding of diagnostic and device regulations, good clinical practice, clinical trial design and execution, clinical pharmacology, and biostatistics.
  • •Ability to communicate and collaborate effectively with stakeholders across clinical, translational, computational, and life sciences functions.
Experience:10+ yearsBiotechPharmaTranslational scienceDrug discoveryClinical trials
Education:
Skills:Cross-functional collaborationLeadershipCommunicationInterpersonal skillsPatient-driven mindset
Tech Stack:AI/MLMachine learningGCPBiostatistics

Company Brief

Insitro
Insitro is a machine-learning-driven drug discovery and development company that integrates high-throughput biology, human genetics, and AI to identify therapeutic targets and design medicines across metabolic and neurodegenerative diseases.
Industry: Biotech
Company Size: Large (251 to 1,000 employees)
Growth: Scaleup
Funding: Series C
Headquarters: South San Francisco, United States
Founded: 2018
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