3 months ago

Scientist, Cell Biology & Antibody Engineering

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 22 hours agoStatus: Live

Job Summary

Scientist to develop and execute antibody screening and characterization on Medra’s Physical AI platform. You will design in vitro and cell-based assays, maintain cell lines, run biophysical characterization (SPR/BLI), and help build autonomous lab workflows, collaborating with roboticists and software engineers in a 100% on-site San Francisco lab.

Location: San Francisco

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Key Responsibilities

•Design, execute, and interpret antibody screening and characterization campaigns across the full funnel—from high-throughput primary hit triage through orthogonal confirmation
•Develop and run cell-based binding and functional assays using flow cytometry to characterize antibodies, VHHs, and other binder formats
•Run biophysical characterization on antibody candidates—including SPR and BLI for affinity and kinetics, and epitope binning—informing go/no-go decisions
•Execute developability assays to assess manufacturability and liability risks early—including thermal stability (DSF/DSC), aggregation/monomericity (HPLC-SEC), hydrophobicity (HPLC-HIC), polyspecificity/non-specific binding, and expression titer
•Maintain and engineer mammalian cell lines (e.g., Expi293, ExpiCHO, HEK293, CHO) and establish cell-based characterization and functional assays

Pay and Benefits

Salary: USD 140,000 - 175,000 annually

Equity and Bonus:Equity

Perks:401kHealth InsuranceDentalPaid LeaveEquity

Key Requirements

•Ph.D. in cell biology, immunology, biochemistry, or a related discipline with 2+ years of industry experience, or a BS/MS with 6+ years of hands-on industry experience
•Strong background in mammalian cell culture and sterile technique
•Deep hands-on expertise in flow cytometry, including high-throughput formats and panel design
•Demonstrated experience designing and executing cell-based functional assays for antibody characterization (binding, potency, mechanism-of-action)
•Working understanding of antibody structure, function, and the therapeutic antibody discovery process

Experience:BiotechnologyLife sciencesAntibody engineering

Education:PhD / Doctorate in Biology

Skills:Flow cytometryAntibody screeningAntibody characterizationCell cultureMammalian cell cultureBiophysical characterizationSPRBLIHPLC-SECHPLC-HICDSFDSCELNExpi293ExpiCHOHEK293CHOAssay developmentAutomation

Tech Stack:Flow cytometrySPRBLIHPLC-SECHPLC-HICDSFDSCExpi293ExpiCHOHEK293CHOCell cultureELN

Company Brief

Medra

Builds a Physical AI Scientist platform that unites robotics, AI, and automated experimentation to run end-to-end lab workflows, accelerate data generation, and accelerate drug discovery through closed-loop, autonomous experimentation.

Industry: Biotech

Company Size: Small (11 to 50 employees)

Growth: Early Stage Startup

Funding: Series A

Headquarters: San Francisco, United States

Founded: 2021

Website LinkedIn Glassdoor

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Medra

3 months ago

Scientist, Cell Biology & Antibody Engineering

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 22 hours agoStatus: Live

Job Summary

Location: San Francisco

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Key Responsibilities

•Design, execute, and interpret antibody screening and characterization campaigns across the full funnel—from high-throughput primary hit triage through orthogonal confirmation
•Develop and run cell-based binding and functional assays using flow cytometry to characterize antibodies, VHHs, and other binder formats
•Run biophysical characterization on antibody candidates—including SPR and BLI for affinity and kinetics, and epitope binning—informing go/no-go decisions
•Execute developability assays to assess manufacturability and liability risks early—including thermal stability (DSF/DSC), aggregation/monomericity (HPLC-SEC), hydrophobicity (HPLC-HIC), polyspecificity/non-specific binding, and expression titer
•Maintain and engineer mammalian cell lines (e.g., Expi293, ExpiCHO, HEK293, CHO) and establish cell-based characterization and functional assays

Pay and Benefits

Salary: USD 140,000 - 175,000 annually

Equity and Bonus:Equity

Perks:401kHealth InsuranceDentalPaid LeaveEquity

Key Requirements

•Ph.D. in cell biology, immunology, biochemistry, or a related discipline with 2+ years of industry experience, or a BS/MS with 6+ years of hands-on industry experience
•Strong background in mammalian cell culture and sterile technique
•Deep hands-on expertise in flow cytometry, including high-throughput formats and panel design
•Demonstrated experience designing and executing cell-based functional assays for antibody characterization (binding, potency, mechanism-of-action)
•Working understanding of antibody structure, function, and the therapeutic antibody discovery process

Experience:BiotechnologyLife sciencesAntibody engineering

Education:PhD / Doctorate in Biology

Tech Stack:Flow cytometrySPRBLIHPLC-SECHPLC-HICDSFDSCExpi293ExpiCHOHEK293CHOCell cultureELN

Company Brief

Medra

Industry: Biotech

Company Size: Small (11 to 50 employees)

Growth: Early Stage Startup

Funding: Series A

Headquarters: San Francisco, United States

Founded: 2021

Website LinkedIn Glassdoor