Scientist, GPCR Biology - San Diego, CA

DSM
San Diego
Workplace: OnsiteFull timeFunction: Research & Scientific (R&D)Education: phdSkills: ["Data analysis","Communication","Problem-solving","Experimental design","Team collaboration"]

Seeking a PhD-level scientist to lead GPCR biology studies, develop cell-based GPCR assays, and collaborate with data science and computational teams to apply in silico discovery methods. You will map binding and signaling determinants, interpret pharmacology data, and contribute to cross-functional decisions in a fast-paced R&D environment focused on taste and oral sensation mechanisms.

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DSM
DSM
4 months ago

Scientist, GPCR Biology - San Diego, CA

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Source: Company careers pageValidated by: Fursa AI
Last checked: 6 hours agoStatus: Live

Job Summary

Seeking a PhD-level scientist to lead GPCR biology studies, develop cell-based GPCR assays, and collaborate with data science and computational teams to apply in silico discovery methods. You will map binding and signaling determinants, interpret pharmacology data, and contribute to cross-functional decisions in a fast-paced R&D environment focused on taste and oral sensation mechanisms.
Location: San Diego
Workplace: Onsite
Employment Type: Full time
Job Function: Research & Scientific (R&D)

Key Responsibilities

  • •Design, build, and run cell-based GPCR assays to study receptor function and enable screening of agonists/antagonists/modulators (e.g., Ca2+ flux, cAMP, IP-One/IP3, β-arrestin, reporter gene, BRET/FRET-based readouts, SPRM), including assay optimization for robustness, throughput, and reproducibility.
  • •Drive GPCR pharmacology and structure–function investigations: interpret potency/efficacy, bias, desensitization/internalization, allosteric modulation, species variants, and key mutagenesis experiments to map binding and signalling determinants.
  • •Collaborate closely with Data Science and Computational teams to apply in silico drug discovery approaches, including molecular docking, structure‑based modeling, and AI/ML‑driven prediction methods, in support of GPCR discovery programs.
  • •Document, analyze, and communicate results through clear experimental design, statistics, and data visualization; contribute to internal reports, invention disclosures, and cross-functional decision-making in a fast-paced environment.

Pay and Benefits

Perks:Learning Budget

Key Requirements

  • •PhD in Cell Biology, Pharmacology, Neurobiology, or closely related discipline, with hands-on, experimental expertise in GPCR biology.
Experience:BiotechDrug discoveryGPCR
Education:PhD / Doctorate
Skills:Data analysisCommunicationProblem-solvingExperimental designTeam collaboration
Languages:English
Tech Stack:GPCRCa2+ fluxCAMPIP-OneIP3Β-arrestinBRETFRETReadoutsMolecular dockingStructure-based modelingAI/MLRPython

Company Brief

DSM
DSM-Firmenich is a global leader in food ingredients, nutrition, fragrances and beauty solutions, formed by the merger of DSM and Firmenich to provide sustainable, science-driven products and services across food, health and personal care industries.
Industry: Chemical Manufacturing
Company Size: Enterprise (1,001+ employees)
Revenue: USD 1B+
Growth: Established Company
Headquarters: Geneva, Switzerland
Founded: 2023
WebsiteLinkedIn