2 months ago

Scientist, GPCR Biology - San Diego, CA

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Last checked: 1 hour agoStatus: Live

Job Summary

Seeking a PhD-level scientist to lead GPCR biology studies, develop cell-based GPCR assays, and collaborate with data science and computational teams to apply in silico discovery methods. You will map binding and signaling determinants, interpret pharmacology data, and contribute to cross-functional decisions in a fast-paced R&D environment focused on taste and oral sensation mechanisms.

Location: San Diego

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Key Responsibilities

•Design, build, and run cell-based GPCR assays to study receptor function and enable screening of agonists/antagonists/modulators (e.g., Ca2+ flux, cAMP, IP-One/IP3, β-arrestin, reporter gene, BRET/FRET-based readouts, SPRM), including assay optimization for robustness, throughput, and reproducibility.
•Drive GPCR pharmacology and structure–function investigations: interpret potency/efficacy, bias, desensitization/internalization, allosteric modulation, species variants, and key mutagenesis experiments to map binding and signalling determinants.
•Collaborate closely with Data Science and Computational teams to apply in silico drug discovery approaches, including molecular docking, structure‑based modeling, and AI/ML‑driven prediction methods, in support of GPCR discovery programs.
•Document, analyze, and communicate results through clear experimental design, statistics, and data visualization; contribute to internal reports, invention disclosures, and cross-functional decision-making in a fast-paced environment.

Pay and Benefits

Perks:Learning Budget

Key Requirements

•PhD in Cell Biology, Pharmacology, Neurobiology, or closely related discipline, with hands-on, experimental expertise in GPCR biology.

Experience:BiotechDrug discoveryGPCR

Education:PhD / Doctorate

Skills:Data analysisCommunicationProblem-solvingExperimental designTeam collaboration

Languages:English

Tech Stack:GPCRCa2+ fluxCAMPIP-OneIP3Β-arrestinBRETFRETReadoutsMolecular dockingStructure-based modelingAI/MLRPython

Company Brief

DSM

Industry: Chemical Manufacturing

Website

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