Principal Product Manager

Natera
United States
Workplace: RemoteFull timeUSD 205,600 - 257,000 annuallyFunction: Product ManagementExperience: 10+ yearsEducation: bachelorsSkills: ["High agency","Cross-functional leadership","Communication","Systems thinking","Agile execution"]

Lead end-to-end product strategy and execution for complex oncology Comprehensive Genomic Profiling software platforms, from order ingestion through lab execution to patient reporting. Serve as a senior domain expert translating scientific and regulatory requirements into scalable specifications, driving roadmap alignment through influence across Engineering, R&D, Commercial, Clinical, Quality, and Regulatory. Own agile delivery, mitigate product risks, and pioneer AI/LLM-native workflows to accelerate discovery and requirements synthesis.

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FursaFursa
Natera
Natera
2 days ago

Principal Product Manager

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Source: Company careers pageValidated by: Fursa AI
Last checked: 12 hours agoStatus: Live

Job Summary

Lead end-to-end product strategy and execution for complex oncology Comprehensive Genomic Profiling software platforms, from order ingestion through lab execution to patient reporting. Serve as a senior domain expert translating scientific and regulatory requirements into scalable specifications, driving roadmap alignment through influence across Engineering, R&D, Commercial, Clinical, Quality, and Regulatory. Own agile delivery, mitigate product risks, and pioneer AI/LLM-native workflows to accelerate discovery and requirements synthesis.
Location: United States
Workplace: Remote
Employment Type: Full time
Job Function: Product Management
Seniority: Mid level

Key Responsibilities

  • •Define multi-year software product roadmaps for critical business units, balancing prototyping and long-term stability.
  • •Lead end-to-end ownership of complex product lifecycles across the user journey from order ingestion to patient reporting.
  • •Translate complex scientific/clinical/technical requirements into robust, scalable software specifications and workflows.
  • •Drive agile product execution by owning backlogs and facilitating Agile ceremonies for timely, high-quality delivery.
  • •Partner with Quality and Regulatory teams to ensure compliance and mitigate product risks without slowing development velocity.

Pay and Benefits

Salary: USD 205,600 - 257,000 annually
Perks:Health InsuranceDentalVisionLife InsuranceDisability Insurance401kParental LeaveCommuter Benefits

Key Requirements

  • •10+ years of product management experience in high-scale software or biotech environments, operating at a Director-level seniority.
  • •Proven ability to build and launch new software products from the ground up (zero-to-one) in a startup or internal incubator environment.
  • •Deep experience working in regulated environments (e.g., FDA design controls, HIPAA, IEC 62304, or ISO standards), with HealthTech/MedTech/genomics experience advantageous.
  • •Strong ability to understand complex technical architectures (APIs, microservices, LIMS, data platforms, event-driven systems) and translate them into product requirements.
  • •Hands-on fluency using LLMs and generative AI tools to accelerate product workflows, requirements generation, or operational insight.
Experience:10+ yearsBiotechGenomicsHealthTechMedTechRegulated industriesStartup environments
Education:Bachelor's
Skills:High agencyCross-functional leadershipCommunicationSystems thinkingAgile execution
Tech Stack:APIsMicroservicesLIMSData PlatformsEvent-driven systemsLLMsGenerative AI

Company Brief

Natera
Develops and commercializes genetic testing and diagnostics focused on reproductive health, oncology, and organ transplant to inform clinical decision-making and improve patient outcomes.
Industry: Diagnostics
Company Size: Enterprise (1,001+ employees)
Revenue: USD 500M to 1B
Growth: Public Company
Valuation: Public Company (Market Cap in USD)
Funding: IPO / Publicly Listed
Headquarters: San Carlos, United States
Founded: 2004
WebsiteLinkedIn