Senior Director, Clinical Pharmacology

BridgeBio
San Francisco
Workplace: HybridFull timeUSD 265,000 - 289,000Function: Executive & General ManagementExperience: 10+ yearsEducation: phdSkills: ["Analytical thinking","Critical thinking","Problem-solving","Communication","Stakeholder management"]

Lead clinical pharmacology and pharmacometrics strategies across cross-functional teams, overseeing population PK, exposure–response, PK/PD, and PBPK models throughout clinical development for small molecules. Manage modeling and simulation to support dose selection and pediatric study design, and oversee bioanalytical CROs and study execution. Author and contribute to key regulatory documents and support interactions with global health authorities by translating results into clear regulatory and stakeholder insights.

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BridgeBio
BridgeBio
4 days ago

Senior Director, Clinical Pharmacology

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Job Summary

Lead clinical pharmacology and pharmacometrics strategies across cross-functional teams, overseeing population PK, exposure–response, PK/PD, and PBPK models throughout clinical development for small molecules. Manage modeling and simulation to support dose selection and pediatric study design, and oversee bioanalytical CROs and study execution. Author and contribute to key regulatory documents and support interactions with global health authorities by translating results into clear regulatory and stakeholder insights.
Location: San Francisco
Workplace: Hybrid
Employment Type: Full time
Job Function: Executive & General Management
Seniority: Director level

Key Responsibilities

  • •Lead clinical pharmacology and pharmacometrics strategy across all stages of clinical development, including pediatric development programs.
  • •Manage development and application of NCA, population PK, exposure–response, PK/PD, and PBPK models to support decision-making across programs.
  • •Oversee modeling and simulation-based analyses for dose selection and study design in pediatric populations, supporting global regulatory submissions and labeling.
  • •Author and contribute to clinical pharmacology sections of regulatory documents (e.g., IB, DSUR, briefing books, NDA/MAA submissions) and support interactions with global regulatory agencies.
  • •Design clinical pharmacology studies, manage study execution and CRO/vendor oversight, and ensure PK data analyses and study-level protocol/report review and approvals.

Pay and Benefits

Salary: USD 265,000 - 289,000
Equity and Bonus:Equity
Perks:401kHealth InsuranceDentalVisionHsaFsaPaid LeaveParental LeaveEquityLearning Budget

Key Requirements

  • •Ph.D. or Pharm.D. in Clinical Pharmacology, Pharmaceutical Sciences, or related discipline, with 10+ years of relevant biotechnology/pharmaceutical industry experience.
  • •Demonstrated track record in population PK, PK/PD, mechanistic modeling (PBPK), and quantitative data analysis to inform clinical development and regulatory strategy; pediatric drug development experience preferred.
  • •Strong understanding of global regulatory guidance related to clinical pharmacology, model-informed drug development, bioanalytical method validation, and GLP/GxP regulations.
  • •Excellent analytical, critical thinking, and problem-solving skills, with the ability to translate complex quantitative findings into actionable insights.
  • •Strong written, verbal, and interpersonal communication skills, including experience presenting to internal teams and external stakeholders.
Experience:10+ yearsBiotechnologyPharmaceutical industryModel-informed drug developmentClinical trialsRegulatory submissionsPediatric drug development
Education:PhD / Doctorate in Clinical Pharmacology or Pharmaceutical Sciences
Skills:Analytical thinkingCritical thinkingProblem-solvingCommunicationStakeholder management
Languages:English
Tech Stack:Population PKPK/PDPBPKPharmacoketricsPharmacologyNCAExposure–responseModeling and simulationBioanalytical method validationGLP/GxP

Company Brief

BridgeBio
Develops medicines for patients with genetic diseases by advancing targeted therapeutics from discovery through clinical development and commercialization, focusing on genetically defined diseases with high unmet medical need.
Industry: Biotech
Company Size: Large (251 to 1,000 employees)
Growth: Public Company
Valuation: Public Company (Market Cap in USD)
Funding: IPO / Publicly Listed
Headquarters: Palo Alto, United States
Founded: 2015
WebsiteLinkedIn