Insitro

1 month ago

Senior Scientist, Cardiac Modeling

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 7 hours agoStatus: Live

Job Summary

Senior Scientist to develop and apply iPSC-derived cardiomyocyte models to study cardiovascular disease, integrating stem cell biology with ML-driven drug discovery. Lead 2D/3D differentiation, generate isogenic disease models, and collaborate with ML, computational biology, and chemistry teams to connect cellular phenotypes to therapeutic targets, onsite in South San Francisco.

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Key Responsibilities

•iPSC-CM Platform & Model Development: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline
•2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality
•Genetic Disease Models: Build and apply isogenic iPSC-CM disease models — including CRISPR-edited lines carrying disease-associated variants — to study cardiovascular pathophysiology
•Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease —contractility, electrophysiology, calcium handling, stress responses— in formats compatible with high-throughput data acquisition
•Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform

Pay and Benefits

Salary: USD 156,000 - 166,000 annually

Equity and Bonus:Equity

Perks:401kMedicalDentalVisionParental LeaveHome OfficeCommuter BenefitsMeal Allowance

Key Requirements

•Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
•Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms
•Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs
•Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease
•Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines

Experience:BiotechDrug discoveryCardiovascularStem cell biologyMachine learning

Education:PhD / Doctorate

Skills:CommunicationCollaborationProblem-solvingLeadershipTeamwork

Languages:English

Tech Stack:IPSCCRISPRHigh-content imagingAutomated microscopy2D3DEHTCardiomyocytesGWASML

Company Brief

Insitro

Insitro is a machine-learning-driven drug discovery and development company that integrates high-throughput biology, human genetics, and AI to identify therapeutic targets and design medicines across metabolic and neurodegenerative diseases.

Industry: Biotech

Company Size: Large (251 to 1,000 employees)

Growth: Scaleup

Funding: Series C

Headquarters: South San Francisco, United States

Founded: 2018

Glassdoor: 2.7

Website LinkedIn Glassdoor

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Insitro

1 month ago

Senior Scientist, Cardiac Modeling

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 7 hours agoStatus: Live

Job Summary

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Key Responsibilities

•iPSC-CM Platform & Model Development: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline
•2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality
•Genetic Disease Models: Build and apply isogenic iPSC-CM disease models — including CRISPR-edited lines carrying disease-associated variants — to study cardiovascular pathophysiology
•Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease —contractility, electrophysiology, calcium handling, stress responses— in formats compatible with high-throughput data acquisition
•Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform

Pay and Benefits

Salary: USD 156,000 - 166,000 annually

Equity and Bonus:Equity

Perks:401kMedicalDentalVisionParental LeaveHome OfficeCommuter BenefitsMeal Allowance

Key Requirements

•Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
•Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms
•Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs
•Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease
•Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines

Experience:BiotechDrug discoveryCardiovascularStem cell biologyMachine learning

Education:PhD / Doctorate

Skills:CommunicationCollaborationProblem-solvingLeadershipTeamwork

Languages:English

Tech Stack:IPSCCRISPRHigh-content imagingAutomated microscopy2D3DEHTCardiomyocytesGWASML

Company Brief

Insitro

Industry: Biotech

Company Size: Large (251 to 1,000 employees)

Growth: Scaleup

Funding: Series C

Headquarters: South San Francisco, United States

Founded: 2018

Glassdoor: 2.7

Website LinkedIn Glassdoor