Senior Scientist, Cardiac Modeling

Insitro
United States
Workplace: OnsiteFull timeUSD 156,000 - 166,000 annuallyFunction: Research & Scientific (R&D)Education: phdSkills: ["Communication","Collaboration","Problem-solving","Leadership","Teamwork"]

Senior Scientist to develop and apply iPSC-derived cardiomyocyte models to study cardiovascular disease, integrating stem cell biology with ML-driven drug discovery. Lead 2D/3D differentiation, generate isogenic disease models, and collaborate with ML, computational biology, and chemistry teams to connect cellular phenotypes to therapeutic targets, onsite in South San Francisco.

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Insitro
Insitro
2 months ago

Senior Scientist, Cardiac Modeling

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Last checked: 16 hours agoStatus: Live

Job Summary

Senior Scientist to develop and apply iPSC-derived cardiomyocyte models to study cardiovascular disease, integrating stem cell biology with ML-driven drug discovery. Lead 2D/3D differentiation, generate isogenic disease models, and collaborate with ML, computational biology, and chemistry teams to connect cellular phenotypes to therapeutic targets, onsite in South San Francisco.
Location: United States
Workplace: Onsite
Employment Type: Full time
Job Function: Research & Scientific (R&D)

Key Responsibilities

  • •iPSC-CM Platform & Model Development: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline
  • •2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality
  • •Genetic Disease Models: Build and apply isogenic iPSC-CM disease models — including CRISPR-edited lines carrying disease-associated variants — to study cardiovascular pathophysiology
  • •Functional Readouts: Develop readouts of cardiomyocyte biology relevant to disease —contractility, electrophysiology, calcium handling, stress responses— in formats compatible with high-throughput data acquisition
  • •Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform

Pay and Benefits

Salary: USD 156,000 - 166,000 annually
Equity and Bonus:Equity
Perks:401kMedicalDentalVisionParental LeaveHome OfficeCommuter BenefitsMeal Allowance

Key Requirements

  • •Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience
  • •Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms
  • •Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs
  • •Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease
  • •Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines
Experience:BiotechDrug discoveryCardiovascularStem cell biologyMachine learning
Education:PhD / Doctorate
Skills:CommunicationCollaborationProblem-solvingLeadershipTeamwork
Languages:English
Tech Stack:IPSCCRISPRHigh-content imagingAutomated microscopy2D3DEHTCardiomyocytesGWASML

Company Brief

Insitro
Insitro is a machine-learning-driven drug discovery and development company that integrates high-throughput biology, human genetics, and AI to identify therapeutic targets and design medicines across metabolic and neurodegenerative diseases.
Industry: Biotech
Company Size: Large (251 to 1,000 employees)
Growth: Scaleup
Funding: Series C
Headquarters: South San Francisco, United States
Founded: 2018
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