Senior Microscope Engineer

Eon Systems
San Francisco
Workplace: OnsiteFull timeUSD 140,000 - 200,000 annuallyFunction: Solutions Engineering & Sales EngineeringExperience: 5+ yearsSkills: ["Collaboration","Optical design and alignment","Troubleshooting","Instrument build experience","Coding"]

Build and scale high-throughput optical microscopes for connectomics, taking a prototype instrument to a production-ready system and replicating it into a small imaging fleet. You’ll design and assemble custom optical, optomechanical, illumination, detection, and control components (e.g., spinning-disk confocal), operate the microscopes for 3D expanded-tissue acquisitions, and troubleshoot and maintain equipment. Produce build documentation so a technician can assemble reliably.

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FursaFursa
Eon Systems
Eon Systems
1 month ago

Senior Microscope Engineer

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Last checked: 5 hours agoStatus: Live

Job Summary

Build and scale high-throughput optical microscopes for connectomics, taking a prototype instrument to a production-ready system and replicating it into a small imaging fleet. You’ll design and assemble custom optical, optomechanical, illumination, detection, and control components (e.g., spinning-disk confocal), operate the microscopes for 3D expanded-tissue acquisitions, and troubleshoot and maintain equipment. Produce build documentation so a technician can assemble reliably.
Location: San Francisco
Workplace: Onsite
Employment Type: Full time
Job Function: Solutions Engineering & Sales Engineering
Seniority: Mid level

Key Responsibilities

  • •Design and build custom, cost-effective high-throughput optical microscopes optimized for expanded tissue.
  • •Take a working prototype through to a production-ready instrument with motorized staging, optimized acquisition, and validated performance.
  • •Operate microscopes to acquire high-resolution 3D image volumes of expanded neural tissue, sustaining throughput and uptime.
  • •Produce build documentation (BOMs, budgets, timelines, and assembly SOPs) and lead replication into a small fleet.
  • •Troubleshoot imaging issues and perform routine maintenance on microscopy equipment.

Pay and Benefits

Salary: USD 140,000 - 200,000 annually

Key Requirements

  • •5+ years designing and building optical microscopy instruments such as spinning-disk confocal or lightsheet systems, with at least one high-throughput microscope built end to end.
  • •Strong optical design and alignment skills, plus hands-on optomechanical build experience (CAD and rapid prototyping a plus).
  • •Practical command of illumination sources, objective/optics selection, and cameras/detectors.
  • •Ability to code for instrument control, automation, and image processing/analysis.
  • •Ability to work collaboratively in a dynamic, fast-paced research environment.
Experience:5+ yearsConnectomicsMicroscopyResearch
Skills:CollaborationOptical design and alignmentTroubleshootingInstrument build experienceCoding
Tech Stack:CADFPGAImage processingInstrument controlAutomationSpinning-disk confocalLightsheetOptomechanics

Company Brief

Eon Systems
Developing high-fidelity brain emulation by building large-scale connectomes and using neurobiological data plus AI to create digital emulations (initial targets include Drosophila and mouse models).
Industry: Scientific Research
Company Size: Micro (1 to 10 employees)
Growth: Early Stage Startup
Headquarters: San Francisco, United States
WebsiteLinkedIn