Director of Office of the CEO, Founder in Residence

BillionToOne
Menlo Park
Workplace: HybridFull timeUSD 203,651 - 225,088 annuallyFunction: Entrepreneurship & Venture BuildingExperience: 6-10 yearsSkills: ["Leadership","Communication","Analytical thinking","Problem solving"]

Director-level leadership role within BillionToOne's Founder in Residence program. You will partner directly with the CEO and Chief of Staff on high-priority strategic and operational initiatives, lead cross-functional projects spanning product, sales, operations, and finance, and translate first-principles thinking and AI-native approaches into accelerated company outcomes in a hybrid SF Bay Area setting.

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BillionToOne
BillionToOne
3 months ago

Director of Office of the CEO, Founder in Residence

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Last checked: 18 hours agoStatus: Live

Job Summary

Director-level leadership role within BillionToOne's Founder in Residence program. You will partner directly with the CEO and Chief of Staff on high-priority strategic and operational initiatives, lead cross-functional projects spanning product, sales, operations, and finance, and translate first-principles thinking and AI-native approaches into accelerated company outcomes in a hybrid SF Bay Area setting.
Location: Menlo Park
Workplace: Hybrid
Employment Type: Full time
Job Function: Entrepreneurship & Venture Building
Seniority: Director level

Key Responsibilities

  • •Own CEO-Priority Projects: Lead one or more of BillionToOne's highest-priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO, including new product launches, go-to-market strategy, business development, operational excellence, and incubation of new business lines.
  • •Find Broken Things and Fix Them: Identify under-performing processes, diagnose root causes, design fixes, and drive end-to-end execution with cross-functional teams.
  • •Cross-Functional Leadership: Lead and influence teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR to understand each function through the projects you lead.
  • •Operate with AI: Use first-principles thinking and AI-native fluency to move faster in ambiguous, fast-moving environments.
  • •CEO and Executive Partnership: Participate in CEO meetings, present to the executive team, and act as a trusted thought partner on company-shaping decisions.

Pay and Benefits

Salary: USD 203,651 - 225,088 annually
Perks:Health Insurance401kPaid LeaveMeal AllowanceEv ChargingGym Membership

Key Requirements

  • •6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
  • •One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt
  • •First-principles thinker with exceptional analytical horsepower
  • •Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
  • •AI-native fluency in using AI tools to move faster and amplify individual leverage
  • •Strong written and verbal communication, including with executives and the Board
  • •Genuine interest in molecular diagnostics and the BillionToOne mission
  • •On-site position (relocation to SF Bay Area required)
Experience:6-10 yearsHealthcareLife sciencesOperational experienceEntrepreneurship
Skills:LeadershipCommunicationAnalytical thinkingProblem solving
Languages:English
Tech Stack:AI

Company Brief

BillionToOne
Develops molecular counting and sequencing technologies for precise genetic testing. Offers noninvasive prenatal tests and rare disease genomic assays to improve detection accuracy and reduce false positives for clinical and commercial labs.
Industry: Diagnostics
Company Size: Medium (51 to 250 employees)
Growth: Growth Stage Startup
Headquarters: Redwood City, United States
Founded: 2016
WebsiteLinkedIn