Xaira Therapeutics

4 weeks ago

Senior Scientist, Computational Biology

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 3 hours agoStatus: Live

Job Summary

Senior Scientist on the Computational Biology team focusing on large-scale single-cell Perturb-seq analyses, building scalable pipelines and integrating multi-omics data to drive therapeutic discovery and AI/ML modeling in a collaborative, fast-paced biotech environment.

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Sr. Manager level

Key Responsibilities

•Own end-to-end computational analysis of Perturb-seq datasets, spanning quality control, biological interpretation, and translation of large-scale single-cell data into actionable insights for therapeutic discovery and AI/ML modeling
•Design and implement standardized analytical frameworks for integrating Perturb-seq data across diverse experimental contexts, such as cell types, library designs, and sequencing platforms, to enable reliable cross-source analysis
•Build and maintain scalable, production-grade bioinformatics pipelines, with an emphasis on reproducibility, modularity, and performance at the scale of large perturbation screens
•Integrate Perturb-seq data with complementary omics modalities, including CITE-seq, ATAC-seq, spatial transcriptomics, as well as external reference datasets, to enrich biological context and support multi-modal analyses
•Partner closely with AI/ML scientists to ensure data products meet modeling requirements, and collaborate with wet-lab scientists to translate experimental design into optimal computational workflows

Key Requirements

•Ph.D. in Computational Biology, Bioinformatics, Genomics, or a related quantitative field, with 5+ years of relevant industry and/or applied research experience
•Deep expertise in single-cell RNA sequencing analysis with Perturb-seq or CRISPR-based perturbation screens
•Experience building and maintaining production bioinformatics workflows (e.g. Nextflow), containerized environments (Docker) and cloud computing platforms (AWS)
•Strong software engineering fundamentals: Python (numpy, pandas, scanpy, scikit-learn), Unix, GitHub
•Ability to independently lead scientific initiatives and communicate quantitative results to wet lab and computational audiences

Experience:5+ yearsBiotechBiotechnologyDrug discoveryGenomicsSingle-cell RNA sequencing

Education:PhD / Doctorate

Skills:LeadershipCommunicationCollaborationMentoringProblem-solving

Languages:English

Tech Stack:PythonNumpyPandasScanpyScikit-learnNextflowDockerAWSUnixGitHubPerturb-seqCRISPRCITE-seqATAC-seqSpatial transcriptomics

Company Brief

Xaira Therapeutics

Xaira Therapeutics is a biotechnology company developing novel targeted therapeutics using proprietary discovery platforms to address serious unmet medical needs. The company focuses on advancing preclinical and clinical-stage programs toward regulatory approval and commercialization.

Industry: Biotech

Website

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Xaira Therapeutics

4 weeks ago

Senior Scientist, Computational Biology

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 3 hours agoStatus: Live

Job Summary

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Research & Scientific (R&D)

Seniority: Sr. Manager level

Key Responsibilities

•Own end-to-end computational analysis of Perturb-seq datasets, spanning quality control, biological interpretation, and translation of large-scale single-cell data into actionable insights for therapeutic discovery and AI/ML modeling
•Design and implement standardized analytical frameworks for integrating Perturb-seq data across diverse experimental contexts, such as cell types, library designs, and sequencing platforms, to enable reliable cross-source analysis
•Build and maintain scalable, production-grade bioinformatics pipelines, with an emphasis on reproducibility, modularity, and performance at the scale of large perturbation screens
•Integrate Perturb-seq data with complementary omics modalities, including CITE-seq, ATAC-seq, spatial transcriptomics, as well as external reference datasets, to enrich biological context and support multi-modal analyses
•Partner closely with AI/ML scientists to ensure data products meet modeling requirements, and collaborate with wet-lab scientists to translate experimental design into optimal computational workflows

Key Requirements

•Ph.D. in Computational Biology, Bioinformatics, Genomics, or a related quantitative field, with 5+ years of relevant industry and/or applied research experience
•Deep expertise in single-cell RNA sequencing analysis with Perturb-seq or CRISPR-based perturbation screens
•Experience building and maintaining production bioinformatics workflows (e.g. Nextflow), containerized environments (Docker) and cloud computing platforms (AWS)
•Strong software engineering fundamentals: Python (numpy, pandas, scanpy, scikit-learn), Unix, GitHub
•Ability to independently lead scientific initiatives and communicate quantitative results to wet lab and computational audiences

Experience:5+ yearsBiotechBiotechnologyDrug discoveryGenomicsSingle-cell RNA sequencing

Education:PhD / Doctorate

Skills:LeadershipCommunicationCollaborationMentoringProblem-solving

Languages:English

Tech Stack:PythonNumpyPandasScanpyScikit-learnNextflowDockerAWSUnixGitHubPerturb-seqCRISPRCITE-seqATAC-seqSpatial transcriptomics

Company Brief

Xaira Therapeutics

Industry: Biotech

Website