Senior Scientist, Computational Biology

Xaira Therapeutics
United States
Workplace: OnsiteFull timeFunction: Research & Scientific (R&D)Experience: 5+ yearsEducation: phdSkills: ["Leadership","Communication","Collaboration","Mentoring","Problem-solving"]

Senior Scientist on the Computational Biology team focusing on large-scale single-cell Perturb-seq analyses, building scalable pipelines and integrating multi-omics data to drive therapeutic discovery and AI/ML modeling in a collaborative, fast-paced biotech environment.

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FursaFursa
Xaira Therapeutics
Xaira Therapeutics
2 months ago

Senior Scientist, Computational Biology

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Source: Company careers pageValidated by: Fursa AI
Last checked: 11 hours agoStatus: Live

Job Summary

Senior Scientist on the Computational Biology team focusing on large-scale single-cell Perturb-seq analyses, building scalable pipelines and integrating multi-omics data to drive therapeutic discovery and AI/ML modeling in a collaborative, fast-paced biotech environment.
Location: United States
Workplace: Onsite
Employment Type: Full time
Job Function: Research & Scientific (R&D)
Seniority: Sr. Manager level

Key Responsibilities

  • •Own end-to-end computational analysis of Perturb-seq datasets, spanning quality control, biological interpretation, and translation of large-scale single-cell data into actionable insights for therapeutic discovery and AI/ML modeling
  • •Design and implement standardized analytical frameworks for integrating Perturb-seq data across diverse experimental contexts, such as cell types, library designs, and sequencing platforms, to enable reliable cross-source analysis
  • •Build and maintain scalable, production-grade bioinformatics pipelines, with an emphasis on reproducibility, modularity, and performance at the scale of large perturbation screens
  • •Integrate Perturb-seq data with complementary omics modalities, including CITE-seq, ATAC-seq, spatial transcriptomics, as well as external reference datasets, to enrich biological context and support multi-modal analyses
  • •Partner closely with AI/ML scientists to ensure data products meet modeling requirements, and collaborate with wet-lab scientists to translate experimental design into optimal computational workflows

Key Requirements

  • •Ph.D. in Computational Biology, Bioinformatics, Genomics, or a related quantitative field, with 5+ years of relevant industry and/or applied research experience
  • •Deep expertise in single-cell RNA sequencing analysis with Perturb-seq or CRISPR-based perturbation screens
  • •Experience building and maintaining production bioinformatics workflows (e.g. Nextflow), containerized environments (Docker) and cloud computing platforms (AWS)
  • •Strong software engineering fundamentals: Python (numpy, pandas, scanpy, scikit-learn), Unix, GitHub
  • •Ability to independently lead scientific initiatives and communicate quantitative results to wet lab and computational audiences
Experience:5+ yearsBiotechBiotechnologyDrug discoveryGenomicsSingle-cell RNA sequencing
Education:PhD / Doctorate
Skills:LeadershipCommunicationCollaborationMentoringProblem-solving
Languages:English
Tech Stack:PythonNumpyPandasScanpyScikit-learnNextflowDockerAWSUnixGitHubPerturb-seqCRISPRCITE-seqATAC-seqSpatial transcriptomics

Company Brief

Xaira Therapeutics
Xaira Therapeutics is a biotechnology company developing novel targeted therapeutics using proprietary discovery platforms to address serious unmet medical needs. The company focuses on advancing preclinical and clinical-stage programs toward regulatory approval and commercialization.
Industry: Biotech
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