ElevateBio

1 day ago

Senior Scientist, LNP, Process Development & Manufacturing

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 18 hours agoStatus: Live

Job Summary

Design and execute LNP formulation studies to support process characterization, technology transfer, and GMP manufacturing readiness for LNP-based drug products. Characterize LNP/tLNP formulations using biophysical and analytical methods (e.g., DLS, zeta potential, encapsulation efficiency, lipid quantification) and interpret data to guide optimization and tLNP development. Collaborate with MSAT, AD, Quality, Manufacturing, and external clients, and support CMC documentation and commercial client evaluations.

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Manufacturing & Production Operations

Seniority: Mid level

Key Responsibilities

•Lead execution of LNP formulation studies supporting process characterization, technology transfer, and manufacturing readiness for LNP-based drug products.
•Partner with cross-functional teams (MSAT, AD, Quality, Manufacturing) and external clients to support process development, scale-up, and technology transfers.
•Characterize LNP/tLNP formulations and evaluate key attributes including size, PDI, zeta potential, encapsulation efficiency, lipid quantification, ligand density, conjugation efficiency, and stability.
•Analyze experimental data to identify process improvement opportunities and communicate findings, project updates, and recommendations to internal and external stakeholders.
•Support commercial efforts by evaluating work packages and proposals from potential clients seeking to manufacture LNP-based drug products.

Pay and Benefits

Salary: USD 150,000 - 200,000 annually

Key Requirements

•Ph.D. in a relevant discipline or BS/MS with strong industry experience in lipid nanoparticle (LNP) development or drug delivery (including 6+ years working with LNP-based products in process development or manufacturing).
•Familiarity with GMP regulations and experience preparing technical documentation supporting CMC activities, technology transfer, and regulatory filings for LNP-based products.
•Proven experience manufacturing LNP-based products and strong hands-on knowledge of LNP formulation, process development, scale-up into GMP manufacturing, LNP optimization, tLNP development, and LNP purification.
•Experience analyzing and interpreting data linking receptor engagement, ligand density, nanoparticle properties, cellular uptake, and delivery performance to guide tLNP optimization.
•Experience with LNP analytical and biophysical characterization techniques such as DLS, zeta potential, encapsulation efficiency assays (e.g., RiboGreen), lipid quantification, and stability assessments.

Experience:6+ yearsLipid nanoparticlesLNP developmentDrug deliveryProcess developmentGMP manufacturingCMCMRNABioconjugation

Skills:Cross-functional collaborationTechnical communicationData analysisProcess improvementTroubleshooting

Languages:English

Tech Stack:LNPTLNPBioconjugationGMPCMCTechnology transferRegulatory filingsDynamic light scattering (DLS)Zeta potentialRiboGreenLipid quantificationFormulation stabilityUPLC/HPLC-CADMRNA process developmentIn-vitro transcription (IVT)ChromatographyAffinityRPIEXStatistical analysis

Company Brief

ElevateBio

Develops and manufactures cell and gene therapies and provides integrated biologics development and manufacturing platforms, partnering with biotech companies to accelerate clinical and commercial production of advanced therapies.

Industry: Biotech

Company Size: Large (251 to 1,000 employees)

Growth: Established Company

Headquarters: Cambridge, United States

Founded: 2017

Website LinkedIn

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ElevateBio

1 day ago

Senior Scientist, LNP, Process Development & Manufacturing

✓ Verified Job

Canonical indexed version, validated from employer's careers page.

Source: Company careers pageValidated by: Fursa AI

Last checked: 18 hours agoStatus: Live

Job Summary

Location: United States

Workplace: Onsite

Employment Type: Full time

Job Function: Manufacturing & Production Operations

Seniority: Mid level

Key Responsibilities

•Lead execution of LNP formulation studies supporting process characterization, technology transfer, and manufacturing readiness for LNP-based drug products.
•Partner with cross-functional teams (MSAT, AD, Quality, Manufacturing) and external clients to support process development, scale-up, and technology transfers.
•Characterize LNP/tLNP formulations and evaluate key attributes including size, PDI, zeta potential, encapsulation efficiency, lipid quantification, ligand density, conjugation efficiency, and stability.
•Analyze experimental data to identify process improvement opportunities and communicate findings, project updates, and recommendations to internal and external stakeholders.
•Support commercial efforts by evaluating work packages and proposals from potential clients seeking to manufacture LNP-based drug products.

Pay and Benefits

Salary: USD 150,000 - 200,000 annually

Key Requirements

•Ph.D. in a relevant discipline or BS/MS with strong industry experience in lipid nanoparticle (LNP) development or drug delivery (including 6+ years working with LNP-based products in process development or manufacturing).
•Familiarity with GMP regulations and experience preparing technical documentation supporting CMC activities, technology transfer, and regulatory filings for LNP-based products.
•Proven experience manufacturing LNP-based products and strong hands-on knowledge of LNP formulation, process development, scale-up into GMP manufacturing, LNP optimization, tLNP development, and LNP purification.
•Experience analyzing and interpreting data linking receptor engagement, ligand density, nanoparticle properties, cellular uptake, and delivery performance to guide tLNP optimization.
•Experience with LNP analytical and biophysical characterization techniques such as DLS, zeta potential, encapsulation efficiency assays (e.g., RiboGreen), lipid quantification, and stability assessments.

Experience:6+ yearsLipid nanoparticlesLNP developmentDrug deliveryProcess developmentGMP manufacturingCMCMRNABioconjugation

Skills:Cross-functional collaborationTechnical communicationData analysisProcess improvementTroubleshooting

Languages:English

Company Brief

ElevateBio

Industry: Biotech

Company Size: Large (251 to 1,000 employees)

Growth: Established Company

Headquarters: Cambridge, United States

Founded: 2017

Website LinkedIn